Effects of multiple doses of simvastatin and artesunate monotherapy on SCHISTOSOMA MANSONI adult worms during infection in hyperlidemic mice

نویسندگان

چکیده

A single dose of simvastatin and artesunate monotherapy cause damage to the reproductive system schistosomes as well severe tegumental in male worms recovered from mice fed high-fat chow. This study aims investigate whether treatment with multipledose regimes may offer more antischistosomal activity advantages than daily dosing For this purpose, nine weeks post-infection, Swiss Webster were gavaged (200 mg/kg) or (300 for five consecutive days euthanized two post-treatment. Adult analyzed using brightfieldmicroscopy, confocal microscopy scanning electron microscopy, presenting damages caused by males females tegument alterations, including peeling, sloughing areas, loss tubercles, bubbles rupture exposing subtegumental tissue. The overall findings revealed potential against Schistosoma mansoni adult worms, addition showing that multiple doses either tegument.KEY WORDS: mansoni; hyperlipidemia; simvastatin; artesunate; microscopy.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Morphometric study of Schistosoma mansoni adult worms recovered from Undernourished infected mice.

Some unfavourable effects of malnutrition of the host on Schistosoma mansoni worm biology and structure have been reported based upon brigthfield microscopy. This paper aims to study by morphometric techniques, some morphological parameters in male and female adult worms recovered from undernourished albino mice in comparison with parasites recovered from well-fed infected mice. Undernourished ...

متن کامل

on translation of politeness strategies in dialogues involving female characters in translations and retranslations of novels translated before and after the islamic revolution of iran and their effects on the image of women: a polysystem theory approach

abstract reception environment has considerable effects on accepting a translation. as the expectations of a target culture and its values and needs change throughout history, its criteria for accepting a translation or rejecting it will change accordingly (gentzler, 2001). the expectations of iran, as the reception environment in the present study, have changed after the islamic revolution. i...

the effects of planning on accuracy and complexity of iranian efl students’ written narrative task performance

this study compared the different effects of form-focused guided planning vs. meaning-focused guided planning on iranian pre-intermediate students’ task performance. the study lasted for three weeks and concentrated on eight english structures. forty five pre-intermediate iranian students were randomly assigned to three groups of guided planning focus-on-form group (gpfg), guided planning focus...

15 صفحه اول

the effect of e-64 on the developmental competence of sheep cocs during in vitro maturation

in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Revista de Patologia Tropical

سال: 2021

ISSN: ['0301-0406', '1980-8178']

DOI: https://doi.org/10.5216/rpt.v50i1.67007