Effects of multiple doses of simvastatin and artesunate monotherapy on SCHISTOSOMA MANSONI adult worms during infection in hyperlidemic mice
نویسندگان
چکیده
A single dose of simvastatin and artesunate monotherapy cause damage to the reproductive system schistosomes as well severe tegumental in male worms recovered from mice fed high-fat chow. This study aims investigate whether treatment with multipledose regimes may offer more antischistosomal activity advantages than daily dosing For this purpose, nine weeks post-infection, Swiss Webster were gavaged (200 mg/kg) or (300 for five consecutive days euthanized two post-treatment. Adult analyzed using brightfieldmicroscopy, confocal microscopy scanning electron microscopy, presenting damages caused by males females tegument alterations, including peeling, sloughing areas, loss tubercles, bubbles rupture exposing subtegumental tissue. The overall findings revealed potential against Schistosoma mansoni adult worms, addition showing that multiple doses either tegument.KEY WORDS: mansoni; hyperlipidemia; simvastatin; artesunate; microscopy.
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ژورنال
عنوان ژورنال: Revista de Patologia Tropical
سال: 2021
ISSN: ['0301-0406', '1980-8178']
DOI: https://doi.org/10.5216/rpt.v50i1.67007